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KMID : 0352519920290030631
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Korea Univercity Medical Journal
1992 Volume.29 No. 3 p.631 ~ p.641
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Effects of Methylprednisolone and Naloxone on Feline Cortical SEPs in Experimental Spinal Cord Injury
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Rho Young-Soon
Choi Young-Seok
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Abstract
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Spinal cord injury may occur during surgical correction of spinal deformity. In this situation, administration of glucocorticoid steroids or opiate receptor antagonists have been known to improve spinal cord damage. Although therapeutic modalities for the management of acute trauma of the spinal cord has yielded conflicting results, controversy continues regarding their effectiveness. We evaluated the effects of methylprednisolone and naloxone on cortical somatosensory evoked potentials (cortical SEPs) measured in 21 cats undergoing compressive injury on the posterior spinal cord.
After induction with pentobarbiturate (50mg/kg. im), a balloon tipped catheter was inserted into the epidural space with the tip located at thoracolumbar junction. Spinal cord compressive injury was produced by balloon inflation for 20 minutes. One hour after injury. a bolus intravenous injection of saline (1 ml/Kg). methylprednisolone (30 mg/Kg). or naloxone(10mg/Kg) were injected. Cortical SEPs were determined after induction of anesthesia. during the spinal cord compressive injury at 5, 10. 15, and 20 minutes. after administration of methylprednisolone or naloxone.
The methylprednisolone group showed a significantly greater improvement in the latencies and amplitudes of the cortical SEPs compared to other two groups. The naloxone group showed less degree of recovery in the cortical SEPs response.
We conclude that in acute spinal cord compressive injury, with the dose used in this study, treatment with methylprednisolone improves neurologic recovery in the cortical SEPs greater than naloxne.
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